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doi: 10.1016/j.autrev.2021.102792 93 De GrootAS

Certain tissues or pathological conditions in the human body may have slightly acidic pH, and improper linker design could trigger hydrazone linker cleavage before reaching the tumor, causing premature payload release

Semaglutide is FDA-approved for both type 2 diabetes (Ozempic, 2017) and chronic weight management (Wegovy, 2021), with extensive Phase 3 clinical trial data including the STEP program and SELECT cardiovascular outcomes trial (PMID: 37952131)